Influence of off-hours admission on outcomes of ischemic stroke: a systematic review and meta-analysis of contemporary studies

OBJECTIVE: The aim of this study was to document pooled evidence on the association between admission during off-hours and/or weekends and the risk of mortality and poor functional outcome in patients with ischemic stroke, as compared to admission during regular working hours and/or weekdays. MATERIALS AND METHODS: We conducted a systematic search using PubMed, EMBASE, and Scopus databases. Observational studies published between 2013 and 2023 that investigated the association between weekend/off-hours admission and outcomes (mortality and functional outcomes) of ischemic stroke were considered for inclusion. A random effects model was used to conduct the analysis, and effect sizes were reported as pooled odds ratio (OR) or hazards ratio (HR) with corresponding 95% confidence intervals. RESULTS: The analysis consisted of 31 studies and found that patients admitted during weekend/off-hours had a higher risk of in-hospital (OR 1.12, 95% CI: 1.06, 1.18), and 1-month post-admittance mortality (OR 1.13, 95% CI: 1.06, 1.20). However, the risk of mortality after 3, 6, and 12 months was not statistically different between the two patient groups. Patients admitted during weekends/off-hours had a slightly higher risk of poor functional outcomes (modified Rankin Scale score of >= 3) at 1-month post-admittance (OR 1.06, 95% CI: 1.00, 1.11). However, after 3, 6, and 12 months, the risk of poor functional outcomes was similar in both patient groups. Egger's test did not suggest the presence of publication bias for any of the outcomes. CONCLUSIONS: Individuals who suffer from ischemic stroke and present outside of regular working hours or on weekends have a higher likelihood of experiencing short-term mortality and unfavorable functional outcomes.