Monoterpene indole alkaloids from Gelsemium elegans .

Two new monoterpene indole alkaloids, Eleganine A () and Eleganine B (), along with 11 known compounds (3-13) were isolated from the stems and leaves of . Compound 1 is a gelsenicine-related monoterpenoid indole alkaloid possessing an iridoid unit. Their structures and absolute configurations of - were established by UV, IR, HR-ESI-MS, NMR spectroscopy, and electronic circular dichroism data analyses. All isolated compounds were evaluated for their anti-inflammatory and inhibiting glucose-induced mesanginal cell proliferation activities. None of them showed activity with IC far beyond 50 M.