Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo .

Diahann T S L Jansen,Monique T A de Beijer,Robbie J Luijten, Kitty Kwappenberg,Anna-Sophia Wiekmeijer,Amy L Kessler,Roel F A Pieterman,Rachid Bouzid,Willem-Jan Krebber,Robert A de Man,Cornelis J M Melief,Sonja I Buschow

Frontiers in immunology（2023）

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摘要

This indicates that a large population of subjects with different HLA types can be covered by selecting a suitable mix of SLPs for therapeutic vaccine design. In conclusion, we designed a set of SLPs capable of inducing multifunctional CD8+ and CD4+ T cells that create important components for a novel therapeutic vaccine to cure cHBV.

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antigen-based

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