Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus -induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock.

Nhu T Q Nguyen,Thien N M Doan, Kei Sato,Christine Tkaczyk,Bret R Sellman,Binh An Diep

Frontiers in immunology（2023）

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摘要

These results demonstrate the potential utility of a mechanically ventilated rabbit model that reproduced hallmark clinical features of hyperdynamic septic shock and the translational potential of immunotherapy targeting virulence factors for the prevention of staphylococcal septic shock.

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Staphylococcus aureus, mechanical ventilated rabbit model, hyperdynamic septic shock, neutralizing monoclonal antibodies, alpha-toxin, Panton-Valentine leukocidin, leukocidin, clumping factor A

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