High CD8 + tumor-infiltrating lymphocytes indicate severe exhaustion and poor prognosis in angioimmunoblastic T-cell lymphoma.

Qiqi Zhu,Yiming Yang,Xueqin Deng,Ningning Chao,Zihang Chen,Yunxia Ye,Wenyan Zhang,Weiping Liu,Sha Zhao

Frontiers in immunology（2023）

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摘要

Our study comprehensively reveals the exhaustion status of CD8TILs and their potential negative impact on AITL prognosis, which facilitates further mechanistic studies and is valuable for guiding immunotherapy strategies.

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关键词

lymphoma,poor prognosis,tumor-infiltrating,t-cell

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