The impact of female BMI on sperm DNA damage repair ability of oocytes and early embryonic development potential in intracytoplasmic sperm injection cycles.
Frontiers in endocrinology（2023）
Abstract
When injected sperm with high DFI into the oocytes of overweight/obese women, resulting in lower fertilization, cleavage, and high-quality embryo rates in ICSI cycles, and the decreased early developmental potential of embryos from overweight/obese patients may be caused by the diminished capacity of oocytes to repair sperm DNA damage.
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Key words
sperm DNA fragmentation index (DFI), overweight/obese, embryo development, fertilization, intracytoplasmic sperm injection
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