Risks of Polymyxin B Nephrotoxicity and Its Precursors in the Intensive Care Unit: A Retrospective Cohort Study.

Hüseyin Özkarakaş, Yeliz Özdemir,Selma Tosun, Zeki T Tekgül, Mehmet U Bilgin,Ozkan Özmuk,Bülent Çalık

Cureus（2023）

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Abstract

We found that 21 (35%) of 60 intensive care unit patients who had no previous history of kidney injury developed kidney injury after being treated with polymyxin B. We identified advanced age, high BMI, and duration of polymyxin B use as independent risk factors. Therefore, we recommend close monitoring of renal function and prompt intervention, particularly in patients with risk factors, during polymyxin B use.

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Key words

carbapenem resistant gram negative infection, sepsis, nephrotoxicity, i?ntensive care unit, acute kidney injury, polymyxin-b

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