Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab.

Sénadé Atsou,Célia Schellenberg,Jeremy Lagrange,Patrick Lacolley,Peter J Lenting,Cécile V Denis,Olivier D Christophe,Véronique Regnault

Journal of thrombosis and haemostasis : JTH（2023）

Cited 0|Views19

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Abstract

TNF-stimulation of hAECs increases both pro- and anti-coagulant activity. Unexpectedly, the increased anti-coagulant activity is sufficient to limit both FVIII- and emicizumab-induced thrombin generation. This protective effect disappears when emicizumab is combined with aPCC.

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