SHIP1 inhibition via 3-alpha-amino-cholestane enhances protection against Leishmania infection

Bidisha Paul Chowdhury,Shibali Das,Neelam Bodhale,Surya Prakash Pandey,Raki Sudan,Neetu Srivastava,John D. Chisholm,William G Kerr,Subrata Majumdar,Bhaskar Saha

Cytokine（2023）

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摘要

•3AC-sensitive SHIP1 expression increases in Leishmania-infected macrophages.•3AC treatment of Leishmania-susceptible BALB/c mice reduces Leishmania infection.•3AC increased anti-leishmanial, but reduced pro-leishmanial, cytokines’ production.•3AC is a novel immunostimulant with anti-leishmanial function.

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leishmania infection,alpha-amino-cholestane

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