Ilexchinene, a new seco-ursane triterpenoid from the leaves of Ilex chinensis with therapeutic effect on neuroinflammation by attenuating the MAPK/NF-κB signaling pathway.

Siyuan Shao,Ruofei Li,Kexin Wang,Wenqi Xia,Baosong Cui,Shuai Li

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

We identified a novel 18,19-seco-ursane triterpenoid from the leaves of I. chinensis and revealed its underlying mechanism of neuroinflammation for the first time. These findings suggest that ilexchinene might possess promising therapeutic effects in neuroinflammation.

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关键词

Ilex chinensis,Ilexchinene,18,19-seco-ursane triterpenoid,Neuroinflammation,Anti-neuroinflammatory activity,MAPK/NF-κB signaling pathway

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