The contribution of reticular basement membrane proteins to basal airway epithelial attachment, spreading and barrier formation: implications for airway remodeling in asthma.

Aileen Hsieh,Chen Xi Yang,May Al-Fouadi,Kingsley Okechukwu Nwozor,Emmanuel Twumasi Osei,Tillie-Louise Hackett

Frontiers in medicine（2023）

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摘要

Airway epithelial cells attach, spread and form a barrier fastest on fibronectin, and collagen-I and these reticular basement membrane ECM proteins may play a protective role in preserving the epithelial barrier during airway remodeling in asthma.

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关键词

basement membrane, extracellular matrix, cell adhesion, lung, epithelial cells, asthma, barrier function

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