Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK.
Frontiers in immunology(2023)
摘要
Our study demonstrates that ibrutinib directly ameliorates CTL exhaustion, and provides evidence for its synergistic use with cancer immunotherapy.
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关键词
immune checkpoint blockade, T-cell exhaustion, ibrutinib, BTK inhibitor, CD8+T cells
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