Synthesis of interpenetrating networks nanogels based on sodium alginate and 2-(dimethylamino) ethyl methacrylate and application as drug release of the anticancer doxorubicin (DOX)

A new one-pot method for the synthesis of interpenetrating polymer networks nanogels of sodium alginate-co-poly (2-(dimethylamino)ethyl methacrylate) [AG-PDMAEMA] with novel properties is described. Monomers solution consists of sodium alginate biopolymer, 2-(dimethylamino)ethyl methacrylate (DMAEMA) monomer, crosslinker, and initiator in water, as water phase, are used to produce water in oil (W/O) emulsion, stabilized by polyethylene glycol sorbitan monolaurate (Tween 80) and sorbitan monooleate (Span 80) at room temperature. CaCl 2 nanoparticles are synthesized and finally added to the emulsion. To obtain interpenetrating networks hydrogel, crosslinking agent N, Nʼ-methylenebisacrylamide (MBA) and Ca 2+ cations are used to crosslink poly(2-(dimethylamino)ethyl methacrylate) and sodium alginate polymers, respectively. Prepared interpenetrating networks nanogel were employed for entrapping and releasing the model anticancer drug doxorubicin (DOX). The obtainedinterpenetrating polymer networks were characterized by field emission scanning electron microscopy (FE-SEM), Brunauer–Emmett–Teller (BET), Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV), thermogravimetric analysis (TGA) and dynamic light scattering (DLS). In addition, the swelling properties of nanogels in water and the release behavior of the model drug from that were also studied.