The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications.

Olga Klaudia Szewczyk-Roszczenko,Piotr Roszczenko,Anna Shmakova,Nataliya Finiuk,Serhii Holota,Roman Lesyk,Anna Bielawska,Yegor Vassetzky,Krzysztof Bielawski

Cells（2023）

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摘要

Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, discuss chemical inhibitors of this process, and discuss potential clinical applications of the endocytosis inhibitors.

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关键词

clathrin-mediated endocytosis, clathrin-independent endocytosis, cell-penetrating peptides, inhibitors of endocytosis

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