CyberKnife based fractionated stereotactic radiotherapy as an upfront treatment for cerebral arteriovenous malformation

•We investigated the therapeutic outcomes of CyberKnife-based fractionated stereotactic radiotherapy (CKFRT) in patients with cerebral arteriovenous malformations (AVMs).•Our data revealed that the overall cumulative probability of complete obliteration at 3 years was 47% with a median time to complete obliteration of 39 months.•Also, the complete obliteration rate of AVM was associated with the radiosurgery-based AVM score, which consisted of AVM volume and location and patients’ age.•Only one (2%) patient had a hemorrhage during the follow-up period.