Ginsenoside Rg1 attenuates D-galactose-induced neural stem cell senescence via the Sirt1-Nrf2-BDNF pathway

With the ageing of society's population, neurodegenerative diseases have become an important factor affecting the quality of life and mortality in the elderly. Since its physiopathological processes are complex and the authorized medications have recently been shown to have several adverse effects, the development of safe and efficient medications is urgently needed. In this study, we looked at how ginsenoside Rg1 works to postpone neural stem cell ageing and brain ageing, giving it a solid scientific foundation for use as a therapeutic therapy for neurodegenerative diseases. This study demonstrated that ginsenoside Rg1 may up-regulate mitochondrial activity, enhance cellular energy metabolism, increase cellular antioxidant capacity, reduce oxidative stress damage, and promote the proliferation and differentiation of neural stem cells through the Sirt1-Nrf2-BDNF pathway, thus delaying the senescence of neural stem cells and mice brain.image