The epidemiological investigation of vitamin D deficiency in northern Henan province

Aim/purpose To analyze the epidemiology of vitamin D deficiency in northern Henan province, to lay the foundation for prevention and treatment of vitamin D deficiency and the vitamin D related diseases. Methods We collected the basic information including gender, age, and vitamin D concentration of 22184 people who detected the 25 hydroxyvitamin D concentration in the Third Affiliated Hospital of Xinxiang Medical University from June 2020 to May 2023, analyzed the vitamin D deficiency distribution in male children population, female children population, male adult population and female adult population; and the differences of 25 hydroxyvitamin D concentration of diabetes mellitus patients in the total investigation population in northern Henan province were also analyzed and compared according to gender, age and different seasons. Results A total of 22184 data were collected from June 2020 to May 2023 in the Third Affiliated Hospital of Xinxiang Medical University; the age range of investigation objects was from 1 month to 93 years old; there were 8176 male people and 14008 female people, accounting for 36.86% and 63.14% in the total investigation population, respectively; there were 1318 diabetes mellitus patients, accounting for 5.94% in the total investigation population; there were 796 males and 522 females, accounting for 60.39% and 39.61% in the total 1318 diabetes mellitus patients, respectively; the investigation results demonstrated that the number of people with vitamin deficiency was 278, the number of people with vitamin insufficiency was 1418, and the number of people with normal vitamin concentration was 20488, accounting for 1.25%, 6.39% and 92.35% in the total investigation population, respectively; in the adult female population, the number of people with vitamin deficiency and with vitamin insufficiency were highest compared the male children population, female population and male adult population; the statistical results demonstrated that there were the significantly statistical differences among vitamin D concentration<25nmol/mL population, vitamin D concentration at 25-49 nmol/mL population, and vitamin D concentration at 50∼80 nmol/mL in female adult population at the different age (P=0.0039); and there were no statistical differences in male children population, male adult population and female children population at different ages and at different vitamin D concentrations (P>0.05); the results demonstrated that there were the significantly differences among vitamin D concentration<25nmol/mL population, vitamin D concentration at 25-49 nmol/mL population, and vitamin D concentration at 50∼80 nmol/mL in adult diabetes mellitus population at gender, age and different seasons. 92.35% people in northern Henan province had the normal vitamin concentration, there were 7.65% people with vitamin insufficiency or vitamin deficiency in northern Henan province; the number of people with vitamin deficiency and with vitamin insufficiency were highest in the adult female population, and there were the significantly statistical differences in female adult population at the different age at different vitamin concentration population and in diabetes mellitus adult population at gender, age and different seasons. Conclusion The incidence rate of vitamin insufficiency or vitamin deficiency in northern Henan province was 7.65%, and the epidemiology of vitamin D deficiency in northern Henan province had the specific characteristics. Those evidences may provide useful information for prevention and treatment of vitamin D deficiency and vitamin D related diseases. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The details of the IRB/oversight body that provided approval or exemption for the research described are given below: I have the right to post this manuscript and confirm that all authors have assented to posting of the manuscript. All relevant ethical guidelines have been followed. Details of the oversight body: Ethics committee of The Third Affiliated Hospital of Xinxiang Medical University suggested that The epidemiological investigation of vitamin D deficiency in northern Henan province is ethical in according with Ethics committee of The Third Affiliated Hospital of Xinxiang Medical University, and agree to conduct relevant experiments. All necessary patient/participant consent has been obtained. I am legally responsible for the content of the article. I have followed all appropriate research reporting guidelines All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present work are contained in the manuscript