Association of HLA-G 3' untranslated region indel polymorphism and its serum expression with susceptibility to colorectal cancer.

Colorectal cancer (CRC) is a significant global health challenge with increasing incidence and mortality rates in developing countries. Genome-wide association studies have identified new low-penetrance genetic variants linked to CRC. This study aimed to explore the relationship between polymorphism and serum expression with CRC. In a case-control configuration, standard PCR was used for genotyping 3' indel polymorphism and ELISA for quantifying soluble HLA-G in plasma. The study revealed a significant association between the rs371194629 deletion allele and CRC, as well as higher soluble HLA-G levels in CRC patients. These findings suggest that HLA-G could be a promising biomarker for CRC, and further research could lead to improved screening and treatment for more personalized care.