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Evaluation of the molecular origin of amide proton transfer-weighted imaging.

Casey Sun,Yu Zhao,Zhongliang Zu

Magnetic resonance in medicine（2023）

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Abstract
The positive APTw signal using high saturation amplitudes could have significant contributions from soluble proteins through CEST, including amide/amine/guanidine proton transfer effects. In contrast, the negative APTw signal using low saturation amplitudes has significant contribution from lipids through rNOE.
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Key words
amide proton transfer–weighted,imaging
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