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Mosaic BRCA1 promoter methylation contribution in hereditary breast/ovarian cancer pedigrees.

Mathias Schwartz,Sabrina Ibadioune,Albain Chansavang,Sophie Vacher,Sandrine M Caputo,Hélène Delhomelle,Jennifer Wong,Khadija Abidallah,Virginie Moncoutier,Véronique Becette,Tatiana Popova,Voreak Suybeng,Antoine De Pauw,Marc-Henri Stern,Chrystelle Colas,Emmanuelle Mouret-Fourme,Dominique Stoppa-Lyonnet,Lisa Golmard,Ivan Bieche,Julien Masliah-Planchon

Journal of medical genetics（2023）

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Abstract
The high prevalence of mosaic meth in patients with breast/ovarian cancer with affected relatives, as well as this first description of a family aggregation of mosaic meth, shows how this de novo event can contribute to hereditary breast/ovarian cancer pedigrees.
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Epigenomics, Heredity, DNA Repair, DNA Methylation
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