A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile .

Monica Rosas-Lemus,Supratim Dey,George Minasov,Kemin Tan,Spencer M Anderson,Joseph Brunzelle,Salvatore Nocadello,Ivan Shabalin,Ekaterina Filippova,Andrei Halavaty,Youngchang Kim,Natalia Maltseva,Jerzy Osipiuk,Wladek Minor,Andrzej Joachimiak,Alexei Savchenko,Wayne F Anderson,Karla J F Satchell

Microbiology resource announcements（2023）

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摘要

causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

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关键词

protein structure-function, Clostridium difficile, structural genomics, pipeline, X-ray, Clostridiodes

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