Electrochemical selenium-catalyzed para -amination of N -aryloxyamides: access to polysubstituted aminophenols.
Organic & biomolecular chemistry(2023)
摘要
Aminophenols are a class of important compounds with various pharmacological activities such as anticancer, anti-inflammatory, antimalarial, and antibacterial activities. Herein, we introduce a mild and efficient electrochemical selenium-catalyzed strategy to synthesize polysubstituted aminophenols. High atom efficiency and transition metal-free and oxidant-free conditions are the striking features of this protocol. By merging electrochemical and organoselenium-catalyzed processes, the intramolecular rearrangement of -aryloxyamides produces -amination products at room temperature in a simple undivided cell.
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关键词
aminophenols,selenium-catalyzed,para-amination,n-aryloxyamides
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