Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer.

Frontiers in oncology（2023）

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摘要

The established organoids with characteristics of MSI-H cancers can be used to study MMRd cancer biology. The orthotopic model, with its distant metastasis and expressing frameshift peptides, is suitable for evaluating the efficacy of neoantigen-based vaccines or anticancer drugs in combination with other therapies.

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关键词

colorectal cancer,metastatic orthotopic mouse model,mouse model,repair-deficient

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