Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma.

Kristina Breitenecker,Viola Hedrich,Franziska Pupp,Doris Chen,Eva Řezníčková,Gregor Ortmayr,Heidemarie Huber,Gerhard Weber,Lorenz Balcar,Matthias Pinter,Wolfgang Mikulits

Frontiers in oncology（2023）

引用 0|浏览3

暂无评分

摘要

Together, these data suggest that the inhibition of ErbBs is synthetic lethal with Rego in Axl-expressing HCC cells, showing a novel vulnerability of HCC.

查看译文

关键词

hepatocellular carcinoma,GAS6,Axl,tyrosine kinase inhibitors,Regorafenib,ErbB

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要