Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease.

Mackenzie Thornton, Nicole Sommer,Mercedes McGonigle,Anil Kumar Ram,Sireesha Yerrathota,Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan,Praveen V Chakravarthi,Sumedha Gunewardena,Jaya Talreja,Pravin Singhal,Timothy A Fields,Patricio E Ray,Navneet K Dhillon,Madhulika Sharma

bioRxiv : the preprint server for biology（2023）

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摘要

Notch3 inhibition has been reported to be an anti-inflammatory strategy for glomerular diseases. Here, using an HIV-1 transgenic mouse model we show that global Notch3 deletion not only improves kidney phenotype but also renal expression of HIV gene, Nef and systemic inflammation which leads to a drastic increase of life span of these mice. Notch3 inhibition can thus play a dual protective role in HIV related chronic diseases.

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关键词

notch3 deletion,chronic kidney disease,systemic inflammation

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