Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer.

Katherine A Alexander,Ruofan Yu,Nicolas Skuli,Nathan J Coffey,Son Nguyen,Christine Faunce,Hua Huang,Ian P Dardani,Austin L Good,Joan Lim,Catherine Li,Nicholas Biddle,Eric F Joyce,Arjun Raj,Daniel Lee,Brian Keith,M Celeste Simon,Shelley L Berger

bioRxiv : the preprint server for biology（2023）

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摘要

- Nuclear speckles shown to reproducibly vary in cancer, predicting patient survival in ccRCC- HIF-2α drives DNA/gene-speckle contacts dependent on identified speckle targeting motifs within HIF-2α- Putative speckle targeting motifs are highly enriched among regulators of gene expression- Partitioning of transcription factor functional programs may be a major biological function of nuclear speckles.

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