Impact of clozapine monotherapy on gut microbiota and metabolism in people with schizophrenia.

We found differences in the diversity of gut microbiota among groups. The association between gut microbiota and glucose lipid metabolic markers was complicated. Gender was an important differentiating factor. has a low abundance. However, it was the only genus associated with glycemic or lipids in each group. Among metabolic syndromes, was positively correlated with most lipids in females but negatively correlated in males, showing gender differences. In female non-metabolic syndromes, lost its probiotic character; instead, showing pathogenicity, which has strong positive correlations with fasting blood glucose and low-density lipoprotein but negative correlations with Apolipoprotein A1. Maybe schizophrenia, taking clozapine, and gender factors influenced the gut microbiota, which complicated our findings. The significance of the results remains to be determined by in-depth studies.