Chimeric RNAs reveal putative neoantigen peptides for developing tumor vaccines for breast cancer.

Brandon Mistretta,Sakuni Rankothgedera,Micah Castillo, Mitchell Rao,Kimberly Holloway,Anjana Bhardwaj,Maha El Noafal,Constance Albarracin,Randa El-Zein, Hengameh Rezaei,Xiaoping Su,Rehan Akbani,Xiaoshan M Shao,Brian J Czerniecki,Rachel Karchin,Isabelle Bedrosian,Preethi H Gunaratne

Frontiers in immunology（2023）

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摘要

Our data provides a framework to identify immunogenic neoantigen candidates from fusion transcripts and suggests a potential vaccine strategy to target the immunogenic neopeptides in patients with tumors carrying the NSFP1-LRRC37A2 fusion.

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关键词

tumor vaccines,putative neoantigen peptides,breast cancer

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