Basic CSF parameters and MRZ reaction help in differentiating MOG antibody-associated autoimmune disease versus multiple sclerosis.

Benjamin Vlad,Ina Reichen, Stephan Neidhart,Marc Hilty, Dimitra Lekaditi,Christine Heuer,Amanda Eisele,Mario Ziegler,Markus Reindl,Andreas Lutterotti,Axel Regeniter,Ilijas Jelcic

Frontiers in immunology（2023）

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摘要

Basic CSF parameters vary considerably in different clinical phenotypes of MOGAD, but Q>10×10 and absence of CSF-restricted OCB are highly useful to differentiate MOGAD from MS. A positive MRZ reaction is confirmed as the strongest CSF rule-out parameter in MOGAD and could be useful to complement the recently proposed diagnostic criteria.

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关键词

MOGAD,multiple sclerosis,cerebrospinal fluid,MRZ reaction,oligoclonal bands,CSF/serum albumin ratio

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