IGF2BP3 mediates the mRNA degradation of NF1 to promote triple-negative breast cancer progression via an m6A-dependent manner.

Xu Zhang,Liang Shi,Han-Dong Sun,Zi-Wen Wang,Feng Xu,Ji-Fu Wei,Qiang Ding

Clinical and translational medicine（2023）

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摘要

TET3-mediated IGF2BP3 accelerated the proliferation of TNBC by destabilising NF1 mRNA via an m6A-dependent manner. This suggests that IGF2BP3 could be a potential therapeutic target for TNBC.

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关键词

breast cancer,mrna degradation,nf1,triple-negative,a-dependent

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