Spermidine suppresses oxidative stress and ferroptosis by Nrf2/HO-1/GPX4 and Akt/FHC/ACSL4 pathway to alleviate ovarian damage.

Chunyang Niu,Dongmei Jiang,Yongni Guo,Zelong Wang, Qian Sun,Xin Wang,Weikang Ling,Xiaoguang An,Chengweng Ji,Shuo Li,Hua Zhao,Bo Kang

Life sciences（2023）

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摘要

SPD alleviates oxidative stress and ferroptosis by regulating the Nrf2/HO-1/GPX4 and Akt/FHC/ACSL4 pathway, which may be a novel potential strategy to protect ovarian oxidative damage.

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关键词

Spermidine,Ovary,Oxidative stress,Autophagy,Ferroptosis,GPX4 signaling

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