Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer.

Maryam Moradi Binabaj,Fereshteh Asgharzadeh,Farzad Rahmani,Abdulridha Mohammed Al-Asady,Milad Hashemzehi,Atena Soleimani,Amir Avan,Saeedeh Mehraban,Elnaz Ghorbani,Mikhail Ryzhikov,Majid Khazaei,Seyed Mahdi Hassanian

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences（2023）

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摘要

This study demonstrating the potent anti-tumor effects of Vactosertib against CRC progression. Our results clearly suggest that this inhibitor could be a promising agent reducing CRC tumor progression when administered either alone or in combination with standard treatment in CRC patients.

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关键词

TGF beta receptor I inhibitor, Vactosertib, EW-7197, 5-FU, Colorectal cancer

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