Metallaphotoredox-enabled aminocarboxylation of alkenes with CO 2

The conversion of CO 2 to valuable chemicals is highly desirable for sustainable development. Among the various methods available, the difunctionalizing carboxylation of alkenes with CO 2 emerges as an exceptionally efficient approach that facilitates the rapid construction of complex carboxylic acids and derivatives. However, existing systems have been limited to monocatalytic strategies and a few specific reaction types. Here we report a synergistic strategy to realize the aminocarboxylation of alkenes with CO 2 , providing efficient and practical synthetic access to valuable β-amino acids. The pivotal role of binaphthol as a photocatalyst in photoredox catalysis is demonstrated, enabling the single-electron activation of alkenes, generating radical anion intermediates. The remarkable aspect of this strategy lies in the efficient merger of photocatalysis and copper catalysis, enabling the rare orthogonal difunctionalization of alkene radical anions under redox-neutral conditions. Moreover, this strategy features mild conditions, high and unique selectivities, good functional group tolerance, facile product derivations and generality in realizing the hydroamination of alkenes.