Synergetic burns treatment by self-adaption release system combined with cold atmospheric plasma

In the tissue remodeling stage of burns, excessive medical therapy can cause scarring by promoting excessive fibroblast proliferation and collagen deposition. Cold atmospheric plasma (CAP) has emerged in biomedicine for its excellent sterilization and wound-healing function, which is expected to reduce the use of drugs in burns treatment. Here, a novel therapy that could rapidly heal burns was developed using a combined self-adaption release system with CAP. The self-adaption release system (Cur-ZIF8@HA) used curcumin (Cur) as the therapeutic drug and ZIF-8 modified with hyaluronic acid (HA) as the carrier. In vitro study results showed that combined treatment methods can inactivate bacteria and enhance fibroblast cells’ migration and proliferation. In vivo animal wound healing studies have demonstrated that the synergistic treatment of Cur-ZIF8@HA and CAP can help fibroblast proliferation and stimulate angiogenesis, indicating effective wound healing. More importantly, CAP can reduce collagen synthesis in granulation tissue recombination and further inhibit scar formation by combining with Cur-ZIF8@HA. In the biomedical field, these findings underscore to a large extent that our research will open up new possibilities for the interaction of nanotechnology with new technologies of physical principles.