Insight into the relationship between resting heart rate and atrial fibrillation: A Mendelian Randomization study.

Marie Klevjer,Humaira Rasheed,Pål R Romundstad,Erik Madssen,Ben M Brumpton,Anja Bye

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology（2023）

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摘要

In contrast with the current observational knowledge of RHR and AF, an inverse causal association between RHR and AF was demonstrated in both linear and non-linear MR for RHR values up to 90 bpm. Further exploring the underlying mechanisms of the genetic instrument for RHR may shed light on whether pleiotropy is biasing this association.

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关键词

Resting heart rate, Atrial fibrillation, Mendelian randomization, Non-linear Mendelian randomization, UK Biobank

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