Blood Glucose Reference Personalization for Subjects with Type 2 Diabetes*

In this paper, we present two simple and novel methods for automatic personalization of target blood glucose concentration values for individuals with Type 2 Diabetes (T2D). The methods can be integrated with any insulin dosing algorithm, or used to provide an individualized reference BG concentration value for medical professionals to consider when determining long-acting insulin doses and other oral medications. The proposed methods were tested in three different simulation models, with different long-acting insulin dosing strategies, and were found to reduce instances of hypoglycemia.