Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids.

Alejandro Velez Lopez,Amanda Waddell,Simona Antonacci, Daniel Castillo,Neha Santucci,Nicholas J Ollberding,Emily M Eshleman,Lee A Denson,Theresa Alenghat

Neurogastroenterology and motility（2023）

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摘要

Patient-derived colonoids demonstrate that microbiota-derived butyrate can dampen human colonic responses to linaclotide. This study supports incorporation of microbiota and metabolomic assessment to improve precision medicine for DGBI patients.

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关键词

colonoids,microbiota‐derived

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