Allogeneic cord blood regulatory T cells decrease dsDNA antibody and improve albuminuria in systemic lupus erythematosus.

Mi-Ae Lyu,Ximing Tang,Joseph D Khoury,Maria Gabriela Raso,Meixian Huang,Ke Zeng,Mitsutaka Nishimoto,Hongbing Ma,Tara Sadeghi,Christopher R Flowers,Simrit Parmar

Frontiers in immunology（2023）

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摘要

UCB-Tregs can decrease inflammatory burden in SLE, reduce auto-antibody production and resolve end organ damage especially, improve kidney function. Adoptive therapy with UCB-Tregs should be explored for treatment of lupus nephritis in the clinical setting.

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关键词

dsdna antibody,systemic lupus erythematosus,lupus erythematosus,allogeneic cord blood,albuminuria

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