Iron oxide nanoparticles induced cytotoxicity, oxidative stress, cell cycle arrest, and DNA damage in human umbilical vein endothelial cells.

Maqsood A Siddiqui,Rizwan Wahab,Quaiser Saquib,Javed Ahmad,Nida N Farshori,Ebtesam S Al-Sheddi,Mai M Al-Oqail,Shaza M Al-Massarani,Abdulaziz A Al-Khedhairy

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)（2023）

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摘要

Overall, our results clearly demonstrated that IONPs have the potential to induce cytotoxicity, DNA damage, cell cycle arrest, and apoptosis in HUVECs mediated through oxidative stress and ROS production. Thus, IONPs are cytotoxic and it should be handled with proper care.

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关键词

nanoparticles,oxidative stress,iron,cytotoxicity,dna damage

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