Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer.

Renhong Huang,Han Wang,Jin Hong,Jiayi Wu,Ou Huang,Jianrong He,Weiguo Chen,Yafen Li,Xiaosong Chen,Kunwei Shen,Zheng Wang

Frontiers in immunology（2023）

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摘要

Hence, our results highlight the molecular mechanisms underlying SLC7A5 effects and lead to a better understanding of the potential benefit of targeting glutamine metabolism in combination with immunotherapy as a new therapy for TNBC.

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关键词

glutamine metabolic reprogramming,breast cancer,slc7a5,triple-negative

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