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Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency.

Jong-Wan Kwon,Jeong-Seop Oh,Sang Hyeok Seok,Hyeok-Won An,Yu Jin Lee, Na Yun Lee, Taehun Ha, Hyeon Ah Kim, Gyeong Min Yoon, Sung Eun Kim, Pu-Reum Oh,Su-Hyung Lee,Dominic C Voon,Dae-Yong Kim,Jun Won Park

Molecular cancer（2023）

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Abstract
Our research unveils the intricate interplay between YAP and Bcl-2 family members, which can lead to synthetic lethality, offering a potential strategy to overcome drug resistance. Importantly, our findings support a personalized medicine approach where combined therapy targeting YAP and Bcl-2, tailored to NF2 and RASA1 status, could effectively manage metastatic GC.
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Key words
metastatic gastric cancer,gastric cancer
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