Interspecies comparison of the early transcriptomic changes associated with hepatitis B virus exposure in human and macaque immune cell populations.

Armando Andres Roca Suarez, Séverine Planel, Xavier Grand,Céline Couturier,Trang Tran, Fabrice Porcheray, Jérémie Becker,Frédéric Reynier, Ana Delgado, Elodie Cascales, Loïc Peyrot, Andrea Tamellini,Adrien Saliou, Céline Elie,Chloé Baum,Bao Quoc Vuong,Barbara Testoni,Pierre Roques,Fabien Zoulim,Uzma Hasan,Isabelle Chemin

Frontiers in cellular and infection microbiology（2023）

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摘要

Our characterization of early transcriptomic changes induced by HBV in humans and cynomolgus macaques represents a useful resource for the identification of shared and divergent host responses, as well as potential immune targets against HBV.

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关键词

HBV, PBMC, transcriptomics, immune response, macaque

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