Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?

Aurélien Couette,Camille Tron,Léonard Golbin,Bénédicte Franck,Pauline Houssel-Debry,Thierry Frouget,Marie-Pascale Morin,Henri Brenier,Michel Rayar,Marie-Clémence Verdier,Cécile Vigneau,Jonathan Chemouny,Florian Lemaitre

European journal of clinical pharmacology（2023）

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摘要

Tacrolimus C appears to be an imperfect reflection of drug exposure. Evaluating AUC using a microsampling approach offers a mini-invasive strategy to monitor tacrolimus treatment in transplant recipients.

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关键词

calcineurin inhibitors, dried blood spots, drug monitoring, kidney transplantation, liver transplantation, pharmacokinetics

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