The Pharmacokinetics of Individual Conjugated Xanthohumol Metabolites Show Efficient Glucuronidation and Higher Bioavailability of Micellar than Native Xanthohumol in a Randomized, Double-Blind, Crossover Trial in Healthy Humans.

Lance Buckett,Nadine Sus,Veronika Spindler,Michael Rychlik,Christian Schoergenhofer,Jan Frank

Molecular nutrition & food research（2023）

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摘要

Metabolism of orally ingested xanthohumol is complex and efficiently converts the parent compound to predominantly glucuronic acid and to a lesser extent sulfate conjugates. The oral bioavailability of micellar xanthohumol is superior to native xanthohumol, making it a useful delivery form for future human trials.

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关键词

bioavailability, clinical trial, drug absorption, micelles, pharmacokinetics, phase II metabolism, xanthohumol glucuronide

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