MicroRNA-221-3p Targets THBS1 to Promote Wound Healing in Diabetes.

Keyan Hu, Xueying Liu,Hongfeng Chang,Yi Zhang, Hui Zhou,Lei Liu,Xin Zhang,Ziying Jiao,Bing Shen,Qiu Zhang

Diabetes, metabolic syndrome and obesity : targets and therapy（2023）

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摘要

Our findings suggested miR-221-3p might exert an essential impact on diabetes WH via inhibition of THBS1 and lack of miR-221-3p possibly results in impaired healing in chronic wounds of type 2 diabetes. Therefore, developing medicine such as chemically modified analogs of miR-221-3p in future could benefit patients with DFU.

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wound healing,diabetes,targets thbs1

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