A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice.

Nagisa Tokunoh,Shigeyuki Tamiya,Masato Watanabe,Toru Okamoto, Jessica Anindita,Hiroki Tanaka,Chikako Ono,Toshiro Hirai,Hidetaka Akita,Yoshiharu Matsuura,Yasuo Yoshioka

Frontiers in immunology（2023）

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摘要

Overall, these results suggest that a nasal vaccine containing inactivated WV can be a highly effective means of protection against SARS-CoV-2 infection.

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关键词

antigen, IgA, inactivated whole-virion, messenger RNA vaccine, nasal vaccine, SARS-CoV-2, upper respiratory tract

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