Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Translational oncology(2023)
摘要
Our results indicate that inhibition of endogenous HS production can significantly inhibit human EC cell growth via promotion of apoptosis and pyroptosis. Endogenous HS may be a promising therapeutic target in EC cells. Novel inhibitors for HS-producing enzymes can be designed and developed for EC treatment.
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关键词
Esophageal cancer,Endogenous H2S,Apoptosis,Pyroptosis,Signaling pathway
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