Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.

Grace Hendrix,Yuliya Lokhnygina,Megan Ramaker,Olga Ilkayeva,Michael Muehlbauer,William Evans,Lisa Rasbach,Robert Benjamin,Michael Freemark,Pinar Gumus Balikcioglu

Endocrinology, diabetes & metabolism（2023）

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摘要

These findings suggest that glucose intolerance in prepubertal or early pubertal children with T1D is accompanied by incomplete FAO while TDD is associated with preferential catabolism of fats relative to amino acids.

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关键词

branched-chain amino acid, fatty acid oxidation, insulin resistance, metabolomics, Type 1 diabetes

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