Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.

Vittoria Lopez,H J Maximilian Schuh,Salahuddin Mirza,Victoria J Vaaßen,Michael S Schmidt,Katharina Sylvester,Riham M Idris,Christian Renn,Laura Schäkel,Julie Pelletier,Jean Sévigny,Annamaria Naggi,Björn Scheffler,Sang-Yong Lee,Gerd Bendas,Christa E Müller

Frontiers in immunology（2023）

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摘要

NPP1 inhibition likely contributes to the anti-cancer effects of heparins, and their specific optimization may lead to improved therapeutics for the immunotherapy of cancer.

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关键词

ectonucleotide pyrophosphatase/phospho-diesterase-1,immunotherapy,npp1,potent inhibitors

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