A robust genomic-based prognostic model for the assessment of cancer stemness and survival for patients with hepatocellular carcinoma

To the Editor: Hepatocellular carcinoma(HCC)is an aggressive malignancy with poor long-term prognosis[1].Liver cancer stem cell(CSC)can drive the metastasis,drug resistance,and recurrence of HCC[2].The regulatory mechanisms about liver cancer stemness have been investigated,which encouraged the identification and characteriza-tion of novel prognostic and therapeutic strategies for HCC[3].